Cytokine gene polymorphisms in multifactorial conditions

Cytokine gene polymorphisms in multifactorial conditions
Koen Vandenbroeck
Boca Raton, FL : CRC Taylor & Francis, 2006.
Call# QR185.8 .C95 C98 2006

From CRC Press Online:

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Discusses modern statistical methods and bioinformatics resources

Provides an up-to-date overview of modern SNP typing methodologies

Illustrates different approaches to bioinformatics and genetic design problems

Presents careful descriptions of studies that relate cytokine markers to diseases and their individual symptomatic presentations

Summarizes genetic association studies on cytokine gene polymorphisms in clearly organized and accessible tables

Contains 14 chapters dedicated to the cytokine genetics of distinct multifactorial conditions

Includes figures that clarify aspects of cytokine biology, linkage disequilibrium patterns, and SNPs in cytokine genes

The literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphisms in cytokine genes. It discusses haplotype structures and linkage disequilibrium patterns in cytokine gene loci; functional biological effects of polymorphisms; and genetic associations with disease. The book documents polymorphisms in the most important cytokine genes, or gene clusters, and their biological and genetic effects in a multitude of distinct multifactorial conditions.

Unique to this book are the "disease-centered" chapters examining the role of cytokine gene polymorphisms in a multitude of multifactorial conditions. The conditions include autoimmune or chronic inflammatory diseases, cardiovascular disease, infectious diseases, and longevity. "This section is a real tour de force" (Grant Gallagher and Michael F. Seldin, March 2006).

Broadening the understanding of the effect of genetic variations on human immune responses, the organization, scope, and content of this book make it a valuable and easily accessible resource. The book integrates genetic, immunological, and clinical information and will serve as a reference for novice and expert geneticists, immunologists, cell biologists and clinicians. It is a must for everyone involved in, or planning, cytokine genetics or immunogenetics studies."